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低功耗高性能電流式感測放大器設計

為了解決Cam Thomas PTT的問題，作者梁文顏 這樣論述：

Table of ContentsRecommendation Letters from Thesis AdvisorsThesis/Dissertation Oral Defense Committee CertificationPreface iiiAbstract ivTable of Contents vList of Figures viiList of Tables xiChapter 1 Introduction 11.1 Memory and Processors 21.2 Sense Amplifiers 31.3 Technology Trends 41.4 Circui

t Trends 51.5 Other Trends 61.6 SRAM Trends 71.7 Associated Challenges 9Chapter 2 A Circuits Survey 102.1 The Two Broad Classes 102.2 Voltage Sensing 122.3 Current Sensing 162.4 Others 20Chapter 3 Development of a Three-Transistor I–V Converter 223.1 Low Drop-Out Voltage Regulator as a I–V Converter

233.2 I–V Converter as a Current Sense Amplifier 253.3 Simplifying the I–V Converter 253.4 Proof of Concept 273.5 Quest for a Better Error Amplifier 293.6 Revisiting the Proof of Concept 31Chapter 4 Implementation of a Current Sense Amplifier 344.1 Sense Amplifier Shut-Down 344.2 Static Power Reduc

tion 364.3 Pulsed Word-Line Operation 374.4 Bit-Line Capacitance—Effect on Delay 394.5 Bias Variation 414.6 Relevant Concerns 43Chapter 5 Conclusion 445.1 Simulation Results 445.2 Considerations for Long Bit-Lines 465.3 Measurements 475.4 Derivative Circuits 495.5 Derivative Use 525.6 Summary 555.7

Final Thoughts 55References 56Appendices 83List of FiguresFigure 1.1 Die micrograph from [Singh et al., 2018] 2Figure 1.2 Layout from [Takemoto et al., 2020] 2Figure 1.3 Package from [Poulton et al., 2019] 4Figure 1.4 Wearable for happiness index from [Yano et al., 2015] 6Figure 1.5 Test chip from [

Song et al., 2017] 7Figure 2.1 Left–right: nMOS common-source, -gate and -drain amplifier configurations 10Figure 2.2 Left–right: pMOS common-drain, -gate and -source amplifier configurations 11Figure 2.3 Bi-stable constructed of two inverters 11Figure 2.4 Regenerative latch transient simulation out

put 11Figure 2.5 nMOS differential pair 12Figure 2.6 nMOS–input pair differential amplifier 13Figure 2.7 Clocked latch with isolation 14Figure 2.8 Current-controlled latch 15Figure 2.9 Left–right: Resistor and nMOS approximates 16Figure 2.10 Left–right: Resistor and pMOS approximates 16Figure 2.11 n

-p-n common-base amplifier 17Figure 2.12 Partial schematic from [Yeo and Rofail, 1995] 17Figure 2.13 Left–right: nMOS and pMOS current mirrors 18Figure 2.14 Current sense amplifier from [Ishibashi et al., 1995] 18Figure 2.15 Current sense amplifier from [Seno et al., 1993] 19Figure 2.16 Current conv

eyor from [Seevinck et al., 1991] 19Figure 2.17 pMOS-neutralised nMOS differential pair 20Figure 2.18 Λ-type negative resistance from [Wu and Lai, 1979] 21Figure 2.19 I D -V D characteristic of the Λ-type negative resistance 21Figure 3.1 Three-transistor I–V converter 22Figure 3.2 Simplified low dro

p-out voltage regulator 23Figure 3.3 Low drop-out voltage regulator configured as a I–V converter 24Figure 3.4 Low drop-out voltage regulator as a current sense amplifier 25Figure 3.5 Reference-free I–V converter 26Figure 3.6 Logic inverters as positive-gain amplifier 26Figure 3.7 Proof of concept d

esign 27Figure 3.8 Proof of concept design transient simulation output 28Figure 3.9 Typical and unintended input(s) of the logic inverter 29Figure 3.10 Normalised absolute gain plot for each inverter input 30Figure 3.11 Connections made for the absolute gain plot 30Figure 3.12 Bias generator for the

absolute gain plot 31Figure 3.13 Error amplifier replacement in the proof of concept design 31Figure 3.14 Three-transistor I–V converter 32Figure 3.15 Corresponding bias generator of Figure 3.14 32Figure 3.16 Simulation circuit for verifying the improved error amplifier 33Figure 3.17 Demonstration

of the three-transistor I–V converter as a current sense amplifier 33Figure 4.1 Actions to achieve desired node characteristics during shut-down 34Figure 4.2 Figure 3.14 modified for shut-down 35Figure 4.3 Corresponding bias generator of Figure 4.2 35Figure 4.4 Shared use of bias generator 36Figure

4.5 Pseudo-differential version of Figure 4.4 37Figure 4.6 Pseudo-differential configuration of Figure 3.14 37Figure 4.7 Pulsed read of a ZERO 38Figure 4.8 Pulsed read of a ONE 38Figure 4.9 Differential development across dynamic bit-lines and csa outputs 39Figure 4.10 Delay behaviour with capacitiv

e bit-line loading 40Figure 4.11 Normalised csa bias current variation with supply voltage 41Figure 4.12 Normalised csa bias current variation with temperature 42Figure 4.13 Mismatch view of Figure 3.14 43Figure 5.1 Test set-up (external trigger connection not drawn) 47Figure 5.2 Oscillogram demonst

rating circuit functionality at VDD = 2.55V 47Figure 5.3 Test set-up photograph 48Figure 5.4 Left–right: Three-transistor I–V converter and its complement 49Figure 5.5 Transfer characteristics of the circuits in Figure 5.4 49Figure 5.6 Four-transistor I–V converter 50Figure 5.7 Corresponding bias ge

nerator of Figure 5.6 50Figure 5.8 Impact of sizing on AC performance 51Figure 5.9 Left–right: V SS -, V DD -referenced and floating optical receiver front ends 52Figure 5.10 Transfer characteristic of floating I–V converter 53Figure 5.11 High output resistance eases filter realisation 53Figure 5.12

Three-transistor I–V converter operating as an open-drain receiver 54Figure A.1 inv symbol 84Figure A.2 Alternate inv symbol 84Figure A.3 inv transistor-level schematic 84Figure A.4 inv4 symbol 85Figure A.5 inv4 transistor-level schematic 85Figure A.6 inv16 symbol 86Figure A.7 inv16 transistor-leve

l schematic 86Figure A.8 nand2 symbol 87Figure A.9 nand2 transistor-level schematic 87Figure A.10 nand2b symbol 88Figure A.11 nand2b gate-level schematic 88Figure A.12 nor2 symbol 89Figure A.13 nor2 transistor-level schematic 89Figure A.14 nor2b symbol 90Figure A.15 nor2b gate-level schematic 90Figu

re A.16 or2 symbol 91Figure A.17 or2 gate-level schematic 91Figure A.18 tinv symbol 92Figure A.19 tinv transistor-level schematic 92Figure A.20 dlat symbol 93Figure A.21 dlat gate-level schematic 93Figure A.22 dlatr symbol 94Figure A.23 dlatr gate-level schematic 94Figure A.24 dlats symbol 95Figure

A.25 dlats gate-level schematic 95Figure A.26 tie0 symbol 96Figure A.27 tie0 transistor-level schematic 96Figure A.28 tie1 symbol 97Figure A.29 tie1 transistor-level schematic 97Figure B.1 bit0 symbol 99Figure B.2 bit0 transistor-level schematic 99Figure B.3 bit1 symbol 100Figure B.4 bit1 transistor

-level schematic 100Figure B.5 blrc symbol 101Figure B.6 blrc cell-level schematic 101Figure B.7 pre symbol 102Figure B.8 pre transistor-level schematic 102Figure B.9 rblrc symbol 103Figure B.10 rblrc cell-level schematic 103Figure B.11 wr symbol 104Figure B.12 wr transistor-level schematic 105Figur

e B.13 anand2 symbol 106Figure B.14 Alternate anand2 symbol 106Figure B.15 anand2 transistor-level schematic 107Figure B.16 ckgen symbol 108Figure B.17 ckgen gate-level schematic 108Figure B.18 peri symbol 109Figure B.19 peri cell-level schematic 110Figure B.20 csa symbol 111Figure B.21 csa transist

or-level schematic 111Figure B.22 kobl symbol 112Figure B.23 Alternate kobl symbol 112Figure B.24 kobl transistor-level schematic 113Figure B.25 kobs symbol 114Figure B.26 kobs transistor-level schematic 114Figure C.1 sram1 symbol 116Figure C.2 sram1 block-level schematic 117Figure C.3 sram2 symbol

118Figure C.4 sram2 block-level schematic 119Figure C.5 sram3 symbol 120Figure C.6 sram3 block-level schematic 121Figure D.1 ainvl symbol 123Figure D.2 ainvl transistor-level schematic 123Figure D.3 ainvs symbol 124Figure D.4 Alternate ainvs symbol 124Figure D.5 ainvs transistor-level schematic 124F

igure D.6 cut symbol 125Figure D.7 cut cell-level schematic 126Figure D.8 inAmp symbol 127Figure D.9 inAmp cell-level schematic 127Figure D.10 CD4007 symbol 128Figure D.11 CD4007 transistor-level schematic 128Figure D.12 LF356 symbol 129Figure D.13 LF356 cell-level schematic 129Figure D.14 TL431 sym

bol 130Figure D.15 TL431 cell-level schematic 130Figure D.16 tialp symbol 131Figure D.17 tialp transistor-level schematic 131Figure D.18 tiasd symbol 132Figure D.19 tiasd transistor-level schematic 132Figure D.20 tiasn symbol 133Figure D.21 tiasn transistor-level schematic 133Figure D.22 tiasp symbo

l 134Figure D.23 tiasp transistor-level schematic 134Figure E.1 nfet and equivalent nMOS symbol 135Figure E.2 pfet and equivalent pMOS symbol 136Figure E.3 Circuit for estimating per-bit junction capacitance 137Figure E.4 Simulation output for estimating per-bit junction capacitance 138Figure E.5 Ci

rcuit for estimating per-bit bit-line leakage current 138Figure E.6 ID-VD characteristics 139Figure E.7 ID-VG characteristics 140Figure E.8 anand2 transistor-level schematic 141Figure E.9 Test board functional blocks 144Figure E.10 Test board block-level schematic 145Figure E.11 Signal source connec

ted to abbreviated input network 148Figure E.12 General form of a typical instrumentation amplifier 150Figure E.13 Inverting integrator section of test board 154List of TablesTable 1.1 Semiconductor memory hierarchy 1Table 5.1 Column height h = 512b 44Table 5.2 Column height h = 1Kb 44Table 5.3 Colu

mn height h = 2Kb 44Table 5.4 Summarised measurement results 48Table A.1 List of standard cells 83Table A.2 inv truth table 84Table A.3 inv4 truth table 85Table A.4 inv16 truth table 86Table A.5 nand2 truth table 87Table A.6 nand2b truth table 88Table A.7 nor2 truth table 89Table A.8 nor2b truth tab

le 90Table A.9 or2 truth table 91Table A.10 tinv truth table 92Table A.11 dlat truth table 93Table A.12 dlatr truth table 94Table A.13 dlats truth table 95Table A.14 tie0 truth table 96Table A.15 tie1 truth table 97Table B.1 List of custom cells 98Table B.2 pre truth table 102Table B.3 wr truth tabl

e 104Table C.1 SRAM cells and read path configurations 115Table D.1 List of other cells 122Table E.1 Transistor performance 140Table E.2 Primary bill of materials 146Table E.3 Additional hardware 147Table E.4 List of instruments 155Table F.1 List of abbreviations 158Table F.2 List of symbols 159Tabl

e F.3 List of AC quantities 160Table F.4 List of DC quantities 161Table F.5 List of partial-swing signals 162Table F.6 List of rail–rail signals 162Table F.7 List of instance names 163

探討猴頭菇對聽力障礙病患之影響及可能機制

為了解決Cam Thomas PTT的問題，作者劉亞筑 這樣論述：

聽力障礙為最常見的神經退化性疾病(Neurodegenerative diseases)之一，而老化及噪音為聽力障礙的主因。衰老過程中耳蝸血流量(Cochlear blood flow, CoBF)會降低而造成毛細胞(Hair cell, HC)缺氧，且粒線體功能障礙會使自由基(Reactive oxygen species, ROS)過量產生，進而破壞聽覺路徑。噪音則破壞聲音傳遞路徑，導致HC纏結，使聽覺神經-螺旋神經元(Spiral ganglion neurons, SGN)變性及死亡。若以上其一傳達路徑受阻斷，則可能造成聽損且提高耳鳴的發生。猴頭菇富含神經滋養因子，可延緩小鼠HC受損

並提升SGN存活率，對聽力達到保護效果，但對人體之影響尚不清楚，因此本研究為探討猴頭菇對臨床聽力障礙患者及耳鳴之相關影響。實驗招募80位嘉義大林慈濟醫院之50-79歲聽力障礙患者，採雙盲試驗分為安慰劑組及猴頭菇組，為期八個月。於第0、4及8個月時，記錄基本資料、耳鳴困擾問卷及聽力檢查，並採血進行生化檢測，如腦源性神經滋養因子(Brain-derived neurotrophic factor, BDNF)及神經滋養因子(Nerve growth factor, NGF)等。結果顯示，本試驗為良好的隨機對照試驗(Randomized controlled trial, RCT)，50-79歲患者

服用猴頭菇後具提升神經滋養因子含量和降低純音聽力檢查(Pure tone audiometry, PTA)閾值的趨勢。進一步以次族群分析後，發現65歲以上患者補充八個月猴頭菇後，可顯著降低聽力閾值和減少語音辨識閾(Speech recognition threshold, SRT)，亦顯著提升NGF含量。總結以上結果，猴頭菇有提升神經生長因子，進而改善聽力障礙之效益，且在65歲以上老年聽力損失患者具有更顯著的效益。