Gamma SL的問題,我們搜遍了碩博士論文和台灣出版的書籍,推薦(美)傑夫基寫的 物理學家用的張量和群論導論 可以從中找到所需的評價。
另外網站新款Arcteryx 始祖鳥GAMMA SL 連帽外套軟殼男装黑色也說明:國外代購商品需14天左右,為代購性質,訂購後除重大瑕疵外無法取消、退換28210 —————————————————————————— 100% 韓國|日本|歐美|得物|澳洲|加拿大|Stock X |台灣or ...
慈濟大學 醫學科學研究所博士班 彭士奕所指導 林皓然的 應用五味子乙素於曼森血吸蟲感染之相關損傷的治療效果 (2021),提出Gamma SL關鍵因素是什麼,來自於血吸蟲病、五味子乙素、吡喹酮、曼氏血吸蟲、纖維化。
而第二篇論文國立陽明交通大學 跨領域神經科學國際研究生博士學位學程 王桂馨、李怡萱所指導 王李馨的 探討在神經退化性疾病中調控核醣核酸結合蛋白MBNL2表現之機轉 (2021),提出因為有 核醣核酸結合蛋白MBNL2、蛋白分解酵素Calpain-2、神經興奮性毒性、肌強直型肌肉萎縮症、阿茲海默症、神經退化、核醣核酸剪接的重點而找出了 Gamma SL的解答。
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物理學家用的張量和群論導論
為了解決Gamma SL 的問題,作者(美)傑夫基 這樣論述:
傑夫基編著的《物理學家用的張量和群論導論》是一部講述張量和群論的物理學專業的教程,用直觀、嚴謹的方法介紹張量和群論以及其在理論物理和應用數學的重要性。本書旨在用一種比較獨特的框架,揭開張量的神秘面紗,使得讀者在經典物理和量子物理的背景理解它。將物理計算中的許多流形公式和數學中的抽象的或者更加概念性公式的聯系起來,對張量和群論的的人來說,這項工作是很歡迎的。 Part Ⅰ Linear Algebra and Tensors 1 A Quick Introduction to Tensors 2 Vector Spaces 2.1 Definition and
Examples 2.2 Span, Linear Independence, and Bases 2.3 Components 2.4 Linear Operators 2.5 Dual Spaces 2.6 Non-degenerate Hermitian Forms 2.7 Non-degenerate Hermitian Forms and Dual Spaces 2.8 Problems 3 Tensors 3.1 Definition and Examples 3.2 Change of Basis
3.3 Active and Passive Transformations 3.4 The Tensor Product Definition and Properties 3.5 Tensor Products of V and V* 3.6 Applications of the Tensor Product in Classical Physics 3.7 Applications of the Tensor Product in Quantum Physics 3.8 Symmetric Tensors 3.9 Antisymme
tric Tensors 3.10 ProblemsPart Ⅱ Group Theory 4 Groups, Lie Groups, and Lie Algebras 4.1 Groups--Definition and Examples 4.2 The Groups of Classical and Quantum Physics 4.3 Homomorphism and Isomorphism 4.4 From Lie Groups to Lie Algebras 4.5 Lie Algebras--Definition, Propert
ies, and Examples 4.6 The Lie Algebras of Classical and Quantum Physics 4.7 Abstract Lie Algebras 4.8 Homomorphism and Isomorphism Revisited 4.9 Problems 5 Basic Representation Theory 5.1 Representations: Definitions and Basic Examples 5.2 Further Examples 5.3 Tensor Pr
oduct Representations 5.4 Symmetric and Antisymmetric Tensor Product Representations 5.5 Equivalence of Representations 5.6 Direct Sums and Irreducibility 5.7 More on Irreducibility 5.8 The Irreducible Representations of su(2), SU(2) and SO(3) 5.9 Real Representations and Com
plexifications 5.10 The Irreducible Representations of sl(2, C)R, SL(2, C) andS0(3, 1)o 5.11 Irreducibility and the Representations of O(3, 1) and Its Double Covers 5.12 Problems 6 The Wigner-Eckart Theorem and Other Applications 6.1 Tensor Operators, Spherical Tensors and Represen
tation Operators 6.2 Selection Rules and the Wigner-Eckart Theorem 6.3 Gamma Matrices and Dirac Bilinears 6.4 ProblemsAppendix Complexifications of Real Lie Algebras and the Tensor Product Decomposition of sl(2, C)R Representations A.1 Direct Sums and Complexifications of Lie Algebras
A.2 Representations of Complexified Lie Algebras and the Tensor Product Decomposition of s[(2, C)R RepresentationsReferencesIndex
應用五味子乙素於曼森血吸蟲感染之相關損傷的治療效果
為了解決Gamma SL 的問題,作者林皓然 這樣論述:
血吸蟲病(Schistosomiasis)是世界上僅次於瘧疾的最重要的寄生蟲病。臨床上,血吸蟲病患會出現肝臟或其他器官纖維化的症狀。目前,血吸蟲病患者以吡喹酮(Praziquantel;PZQ)治療為主。然而,雖然 PZQ 能有效殺死血吸蟲蟲,它不能防止病患的再次感染或治療肝臟纖維化。而目前的治療方法也不足以治癒肝臟纖維化。除此之外,目前已在眾多體內和體外的研究中發現了血吸蟲對PZQ的抗藥性。因此,我們迫切的需要尋找新的有效治療藥物。目前五味子植物中的五味子乙素(Schisandrin B;Sch B)已被證明可以預防各種不同的肝臟損傷。因此,我們在此研究使用Sch B治療因曼森血吸蟲(Sc
histosoma mansoni)誘發的各種器官損傷的潛力。本研究的結果顯示,Sch B可通過抑制發炎小體的活化和細胞凋亡,以及調節免疫反應,來治療因曼森血吸蟲誘導的肝臟纖維化。此外,Sch B可破壞雄性成蟲,從而有助於減少產卵量並減輕病變。我們進一步的實驗發現,PZQ-Sch B 治療可對血吸蟲病產生更有效的治療反應。這種治療策略可以保護與曼森血吸蟲感染相關的器官損傷,包括肝臟、脾臟、腸道和肺部。此外,PZQ-Sch B的治療提高了感染小鼠的存活率,並且達到更好的預後。總的來說,Sch B對於治療血吸蟲病相關的肝臟損傷和全身併發症可能是一個很有效的藥物。
探討在神經退化性疾病中調控核醣核酸結合蛋白MBNL2表現之機轉
為了解決Gamma SL 的問題,作者王李馨 這樣論述:
中文摘要 iAbstract iiContents iiiIntroduction 1Myotonic dystrophy type 1 (DM1) 1Cerebral involvement of adult-onset DM1 2Genetic basis of DM1 4Molecular mechanism in DM1 4Mouse models of DM1 with expression of CUG repeats 6RNA-binding protein: Muscleblind-like (MBNL) family
8MBNL1 and MBNL2 knockout mice 9Calcium-dependent cysteine protease: Calpain 11Calpain-1 and -2 11Calpain-1 and -2 deficient mice 12Calpain-1 and -2 in neurodegeneration 13Alzheimer’s disease (AD) 14Disease stages of AD 14Clinical presentations of AD 15Brain atrophy of AD
15Two pathological hallmarks of AD 16The aims of the study 20Materials and methods 211. Animals 212. Primary hippocampal neuron culture, drug treatment, virus infection and transfection 213. Cell culture and transient transfection 234. Total protein extraction and sub
cellular fractionation 245. Immunoprecipitation (IP) 256. Immunoblotting analysis 257. RNA preparation, RT-PCR and splicing analysis 268. Immunofluorescence staining and immunohistochemistry 279. Quantification of fluorescent images of brain sections 2910. Quantif
ication of fluorescent images of neurons 3011. Antibodies 3012. Plasmids 3113. Statistical analysis 31Results 331. Characterize the role of MBNL2 in neuronal maturation1.1. MBNL2 is expressed postnatally and increased as neuronal maturation 331.2. MBNL2 expression
is required for promoting adult pattern of RNA processingand neuronal differentiation 342. Determine how neurodegenerative conditions reduce MBNL2 expression2.1. Glutamate-induced excitotoxicity reduces MBNL2 protein expression viaNMDAR activation 352.2. NMDAR-mediated Calpain-2 acti
vation causes MBNL2 protein degradation 362.3. Calcium-dependent nuclear translocation of CAPN2 is associated with reducedMBNL2 expression 382.4. Dysregulated calcium homeostasis reduces MBNL2 expression 392.5. Enhanced nuclear translocation of CAPN2 occurs in the EpA960/CamKII-Cre
brain 402.6. Enhanced nuclear translocation of CAPN2 in neurodegeneration recapitulates thefetal developmental pattern 413. Explore the possibility of the reduced MBNL2 expression associated re-induced fetalpattern of RNA processing as a common feature among neurodegenerative disorders3.
1. Enhanced nuclear translocation of CAPN2, reduced MBNL2 expression and associated aberrant MBNL2-regulated alternative splicing in the degenerative brains of AD 41Discussion 44Perspective 48References 49List of figuresFigure 1. MBNL2 is expressed postnatally and increased with bra
in maturation 64Figure 2. MBNL2 is expressed in the more differentiated cells during hippocampusmaturation 65Figure 3. MBNL2 is expressed ubiquitously in the adult mouse brain 66Figure 4. MBNL2 is expressed in the neurons, oligodendrocytes and astrocytes 67Figure 5. The knockdown
efficiency of MBNL2 shRNAs in cultured neurons 68Figure 6. The alternative splicing and polyadenylation of MBNL2 targets show a fetal to adult transition during neuronal differentiation 70Figure 7. MBNL2 depletion disrupts the developmental RNA processing transition in cultured neurons
71Figure 8. MBNL2 depletion impairs dendrite maturation in cultured neurons 72Figure 9. Glutamate treatment induces excitotoxicity in mature cultured neurons showing condensed nucleus 74Figure 10. Glutamate-induced excitotoxicity reduces MBNL2 protein level in mature cultured neurons 75
Figure 11. Glutamate reduces MBNL2 level via NMDAR activation in cultured neurons 77Figure 12. NMDAR-mediated MBNL2 reduction is calcium dependent 78Figure 13. The alternative splicing and polyadenylation of MBNL2 targets are disrupted in neurons treated with glutamate or NMDA 79Figure 14.
MBNL2 mRNA level is unchanged in cultured neurons treated with glutamate or NMDA 81Figure 15. MBNL2 protein is stable in the neurons 82Figure 16. NMDAR signaling-mediated MBNL2 reduction requires calpain activity incultured neurons 83Figure 17. Protein expression of CAPN1 and CAPN2 are alte
red in NMDA-treatedneurons 84Figure 18. MBNL2 binds to both CAPN1 and CAPN22 in HEK293 cells 85Figure 19. Knockdown efficiency of CAPN1 or CAPN2 shRNAs in neurons 86Figure 20. NMDAR-mediated calpain-2 activation causes MBNL2 degradation inneurons 87Figure 21. Depletion of CAPN2 preserves
MBNL2-regulated alternative splicing andpolyadenylation in neurons upon NMDA treatment 88Figure 22. CAPN2 is predominantly expressed in the cytoplasm of mature neurons 90Figure 23. NMDA treatment induces the nuclear translocation of CAPN2 in neurons 91Figure 24. NMDAR-mediated MBNL2 reduct
ion requires calpain-2 expression in thenucleus and cytoplasm of neurons 92Figure 25. NMDA-induced nuclear translocation of CAPN2 requires calcium 93Figure 26. Nuclear translocation of CAPN2 involves in MBNL2 degradation 94Figure 27. Dysregulated calcium homeostasis induces the nuclear tran
slocation of CAPN2 and reduced MBNL2 expression in neurons 95Figure 28. CAPN2 depletion preserves MBNL2 expression in the neurons with dysregulated calcium homeostasis 96Figure 29. Effect of CAPN2 depletion on the RNA processing pattern of MBNL2 targets in A23187-treated neurons 97Figure 30
. CAPN2 nuclear translocation is occurred in the EpA960/CaMKII-Cre mouse brains 98Figure 31. Nuclear-to-cytoplasmic distribution of CAPN2 during neuronal differentiation 99Figure 32. Nuclear translocation of CAPN2 occurs in the APP/PS1 and THY-Tau22brains 100Figure 33. Reduced MBNL2 express
ion in the APP/PS1 and THY-Tau22 brains 101Figure 34. Aberrant MBNL2-regulated alternative splicing in the APP/PS1 and THY-Tau22 brains 102
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