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Radiation-Oncology Therapy

為了解決Oncology的問題，作者Beriwal, Sushil,Huq, M. Saiful,Boyiadzis, Michael M. 這樣論述：

Sushil Beriwal, MD, is Professor of Radiation Oncology and Director, Residency, Department of Radiation Oncology, University of Pittsburgh School of Medicine. Mohammed Saiful Huq, PhD, is Professor Radiation Oncology, Director of Medical Physics Division, Department of Radiation Oncology, Universi

ty of Pittsburgh School of Medicine.Michael Boyiadzis, MD, M.H.Sc, is Associate Professor of Medicine and Translational Science, Division of Hematology-Oncology, University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center.

Oncology進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Oncology的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Acceleration of the Em, MM, and Other Monotone Algorithms for Modern Applications

為了解決Oncology的問題，作者Varadhan, Ravi,Zhou, Hua 這樣論述：

Dr. Varadhan is an Associate Professor of Oncology in the Division of Biostatistics and Bioinformatics at the Sidney Kimmel Comprehensive Cancer Center (SKCCC). He is also a core faculty in the Center on Aging and Health and the Center for Drug Safety and Effectiveness. Dr. Varadhan is a well-known

expert in several areas of biostatistics. He is an expert in the area of patient-centered outcomes research (PCOR), where he focuses on developing statistical methods that inform evidence-based individualized medicine. He has a particular interest in Bayesian methods for exploring heterogeneity of t

reatment effect (HTE). He has developed numerous algorithms and software for solving high-dimensional optimization problems arising in statistical modeling. Hua Zhou teaches and does research in biostatistics at the University of California, Los Angeles (UCLA). She received her Ph.D. in 2008 from th

e Department of Statistics at Stanford University.

以疾病不確定感理論發展整合性心動健康網路照顧模式提升心房顫動病人因應策略之成效探討

為了解決Oncology的問題，作者謝慧玲 這樣論述：

正文目錄正文目錄『表』目錄 IV『圖』目錄 V『附錄』目錄 VII中文摘要 VIII英文摘要 X第一章 緒論 1 第一節 研究背景、動機及重要性 1 第二節 研究目的 7第二章 文獻查證 8 第一節 心房顫動疾病簡介 8 第二節 疾病不確定感理論 15 第三節 疾病不確定感相關研究 22 第四節 整合性健康網路照顧模式的發展及運用 31第三章 研究架構與假設 36 第一節 研究架構 36 第二節 研究假設 37 第三節 名詞界定 38第四章 研究方法與過程 43 第一節 研究設計 43 第二節 研究對象及場所 45 第三節 研究工具 46

第四節 研究工具之信效度檢定 52 第五節 研究過程 59 第六節 研究倫量 63 第七節 資料處理與統計分析 64第五章 研究結果 66 第一節 心房顫動病人的基本屬性68 第二節 心房顫動病人的症狀困擾、疾病知識、社會支持、疾病不確定感、因應策略及心理困擾之前後測情形 76 第三節 介入「整合性心動健康網路照顧模式」對於心房顫動病人症狀困擾、疾病知識、社會支持、疾病不確定感、因應策略及心理困擾之成效 85第六章 討論 107 第一節 心房顫動病人的基本屬性現況分析 108 第二節 介入「整合性心動健康網路照顧模式」對於改善心房顫動病人症狀困擾之成效 111

第三節 介入「整合性心動健康網路照顧模式」對於改善心房顫動病人疾病知識之成效 113 第四節 介入「整合性心動健康網路照顧模式」對於改善心房顫動病人社會支持之成效 115 第五節 介入「整合性心動健康網路照顧模式」對於改善心房顫動病人疾病不確定感之成效 117 第六節 介入「整合性心動健康網路照顧模式」對於改善心房顫動病人因應策略之成效 119 第七節 介入「整合性心動健康網路照顧模式」對於改善心房顫動病人心理困擾之成效 121 第八節 研究限制 124第七章 結論與建議 125 第一節 結論 125 第二節 建議 127參考文獻 129附錄 141『表』目錄表1. 資料處理

與分析 65表2. 心房顫動病人之人口基本屬性 70表3. 心房顫動病人的疾病特性 74表4. 心房顫動病人症狀困擾、疾病知識、社會支持、疾病不確定感、因應策略及心理困擾之前測與後測結果 83表5. 以 GEE 方法探討整合性心動健康網路照顧模式於心房顫動病人症狀困擾改變之成效 86表6. 以 GEE 方法探討整合性心動健康網路照顧模式於心房顫動病人疾病知識改變之成效 89表7. 以GEE方法探討整合性心動健康網路照顧模式於心房顫動病人社會支持改變之成效 92表8. 以GEE方法探討整合性心動健康網路照顧模式對於心房顫動病人疾病不確定感之改變成效 95表9. 以GEE方法探討整合性心動健康網路

照顧模式對於心房顫動病人因應策略改變之成效 98表10. 以GEE方法探討整合性心動健康網路照顧模式對於心房顫動病人心理困擾改變之成效 103『圖』目錄圖1. 不確定感理論架構 21圖2. 研究架構圖 36圖3. 研究設計 44圖4. 流程圖 67圖5. 兩組在第三版症狀頻率-嚴重程度評估量表之症狀頻率次量表平均分數於前測、後測第一個月、第三個月與第六個月的變化 87圖6. 兩組在心房顫動知識量表平均分數於前測、後測第一個月、第三個月與第六個月的變化 90圖7. 兩組在醫療社會支持量表平均分數於前測、後測第一個月、第三個月與第六個月的變化 93圖8. 兩組在中文版Mishel疾病不確定感量表平

均分數於前測、後測第一個月、第三個月與第六個月的變化 96圖9. 兩組在簡易因應量表之應對因應策略次量表平均分數於前測、後測第一個月、第三個月與第六個月的變化 99圖10. 兩組在簡易因應量表之迴避因應策略次量表平均分數於前測、後測第一個月、第三個月與第六個月的變化 100圖11. 兩組在醫院焦慮憂鬱量表平均分數於前測、後測第一個月、第三個月與第六個月的變化 104圖12. 兩組在醫院焦慮憂鬱量表之焦慮次量表平均分數於前測、後測第一個月、第三個月與第六個月的變化 105圖13. 兩組在醫院焦慮憂鬱量表之憂鬱次量表平均分數於前測、後測第一個月、第三個月與第六個月的變化 106『附錄』目錄附錄一

心房顫動病人基本屬性量表 附錄一附錄二 第三版症狀頻率-嚴重程度評估量表之症狀頻率次量表 附錄二附錄三 心房顫動知識量表 附錄三附錄四 醫療社會支持量表 附錄四附錄五 中文版Mishel疾病不確定感量表 附錄五附錄六 簡易因應量表 附錄六附錄七 醫院憂鬱焦慮量表 附錄七