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The Night Before Christmas Pop Up Book: A Pop-Up Edition

為了解決work it的問題，作者Moore, Clement 這樣論述：

This magnificent Christmas Eve poem is brought to life in this pop-up edition of the #1 New York Times best seller The Night Before Christmas. ’Twas the night before Christmas, when all through the house, Not a creature was stirring, not even a mouse... This holiday season enjoy everyone’s favor

ite Christmas Eve poem with this beautiful pop-up book. Every child knows the words to this captivating story, and this delightful edition provides an exciting 3D reading experience for children and parents alike. Join Dasher, Dancer, Prancer, Vixen, Comet, Cupid, Donder, and Blitzen and dash your w

ay through these dynamic pages. Not only will this Christmas poem spread holiday cheer, it will engage your child and encourage a love of reading. This edition includes: - 3D pop-up elements that offer a new take on this nostalgic Christmas classic - A beautifully designed hardcover with an embosse

d foil-stamped cover - Clement C. Moore’s original text, including a nod to Dutch references in the poem, specifically the Dutch name ＂Donder,＂ which translates to ＂thunder＂ - Stunning artwork by #1 New York Times best-selling illustrator Charles Santore. Start a new family tradition this year or

carry on your own with this illuminating edition of a timeless tale. You’ll be sharing this holiday classic with children and family for years to come. The work of New York Times bestselling children’s book illustrator Charles Santore has been widely exhibited in museums and celebrated with recognit

ions such as the prestigious Hamilton King Award, the Society of Illustrators Award of Excellence, and the Original Art 2000 Gold Medal from the Society of Illustrators. He is best known for his luminous interpretations of classic children’s stories, including The Little Mermaid, Alice’s Adventures

in Wonderland, Snow White, and The Wizard of Oz.

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以計畫行為理論探討我國海軍女性兵科軍官派任艦艇意圖之研究

為了解決work it的問題，作者林美菁 這樣論述：

隨著時代的轉變，性別平等意識提高，世界各國對兩性平權越來越重視。近年來國內有關女性從軍議題的研究日益增多，但切入探討的主題略有所不同。本研究係以我國海軍女性兵科軍官為研究對象，以計畫行為理論透過文獻分析法與問卷調查法來了解女性軍官的派任軍艦職務的意圖。研究結果發現：一、計畫行為理論的預測力在本研究中獲得支持，可用於解釋我國女性兵科軍官派任艦艇意圖的影響因素。二、我國海軍女性兵科軍官在職場工作仍舊面臨傳統的壓力與挑戰，以致在行為態度表現上呈現猶豫之現象，對於投入艦艇工作缺乏信心與意願。三、我國海軍女性兵科軍官投入軍艦工作的行為態度、主觀規範、知覺行為控制，分別都會影響行為意圖。四、年齡及畢業班

隊兩項背景變項對行為態度、行為意圖的表現有顯著差異；而從軍年資及階級對知覺行為控制上有顯著差異；艦艇資歷對行為態度及知覺行為控制上有顯著差異。

Ada Lovelace: The World’s First Computer Programmer

為了解決work it的問題，作者Cox, Annabelle 這樣論述：

While much has been written about the 'father of computers' Charles Babbage and Alan Turing, the pioneer of computer science, many trailblazing female computer programmers have slipped beneath the radar. One of these is Ada Lovelace. A Countess and daughter of the infamous Lord Byron, Lovelace co

uld have lived a very comfortable if unremarkable life, but instead she became a renowned mathematician and writer. She is chiefly known for her work with Charles Babbage, the aforementioned 'father of computers'. But it was actually Ada and not Babbage who was the first person to recognize that the

machine had applications beyond pure calculation. She created the first algorithm intended to be carried out by such a machine and, as a result, she is regarded as the world's very first computer programmer. Her life is fascinating, taking in social and educational exploits with the leading scienti

sts and writers of her day, including Charles Dickens. This new biography seeks to acquaint the reader with all the various milestones of an inspiring life and career.Ada Lovelace is increasingly becoming recognized as a true icon for women in technology. With girls and young women being encouraged

ever more into the fields of mathematics, technology and science (fields previously dominated by men), women such as Ada are incredibly powerful figureheads with influential legacies. Her story is an inspiration to anyone seeking to break new ground in their chosen field.

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決work it的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.