WIK的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列包括賽程、直播線上看和比分戰績懶人包

Infinite Illusions Coloring Book: Eye-popping Designs on a Dramatic Black Background

為了解決WIK的問題，作者Wik, John 這樣論述：

The dark backgrounds for each of these imaginative illustrations provide a striking atmosphere that will perfectly highlight an artist's choice of colors. Over 30 full-page designs feature a wild mix of interlocking, star-shaped, snowflake, swirling, and other hypnotic patterns. Pages are perforated

and printed on one side only for easy removal and display. Specially designed for experienced colorists, Infinite Illusions and other Creative Haven(R) adult coloring books offer an escape to a world of inspiration and artistic fulfillment. Each title is also an effective and fun-filled way to rela

x and reduce stress. Self-taught artist John Wik is a graphic designer and a maker of jewelry.

WIK進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決WIK的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Dimensions Adult Coloring Book

為了解決WIK的問題，作者Wik, John (ART) 這樣論述：

Here's your doorway to another coloring dimension. Thirty-one original designs feature big, bold mandala patterns. The central motifs are surrounded by wavy and edgy borders that create the optical illusion of depth. Pages are perforated and printed on one side only for easy removal and display. Spe

cially designed for experienced colorists, Dimensions and other Creative Haven(R) adult coloring books offer an escape to a world of inspiration and artistic fulfillment. Each title is also an effective and fun-filled way to relax and reduce stress. Self-taught artist John Wik is a graphic design

er and a maker of jewelry.

Energy expenditure during a resistance training exercise in the healthy population

為了解決WIK的問題，作者MUHAMMAD ADEEL 這樣論述：

Background: Energy expenditure (EE) during resistance or strength training (RT/ST) exercise produces great fitness and health benefits for humans, but limited studies have investigated EE directly during resistance exercises. EE through metabolic equivalent (MET) and oxygen consumption (VO2) estima

tion during resistance workouts in humans can be modeled by using cardiorespiratory parameters and surface electromyography (sEMG) of local muscles.Objective: To determine energy cost during three resistance workouts comprising three exercises in stage 1. And to estimate energy cost during six resis

tance workouts consisting of three different exercises from cardiorespiratory parametersand sEMG of body muscles during stage 2.Methods: During stage 1, ten participants were enrolled into two groups: an untrained (n = 5, with no weight training experience) and a trained group (n = 5, with 2 months’

weight training experience). Each participant completed three training sessions on separate days. While wearing a mask for indirect calorimetric measurements, each participant completed training sessions carried out with three dumbbell exercises: bent-over row (BOR), deadlift (DL), and lunge (Lg).

METs, EE, respiratory exchange ratio (RER), heart rate (HR), systolic and diastolic blood pressure (SBP & DBP), and Borg rate of perceived exertion (RPE) were measured. During stage 2, eleven participants were recruited into two groups; an untrained (n = 5) and a trained group (n = 6) and they compl

eted six training sessions. The three types of dumbbell exercises performed are shoulder press, deadlift, and squat. The METs, RER, HR, SBP, DBP, blood lactate (BL), RPE, and sEMG of both sidesmiddle deltoid, lumbar erector spinae, quadriceps, and hamstring were measured. The MET from cardiorespirat

ory parameters and VO2 from the sEMG root mean square (RMS) of the investigated muscles were predicted using generalized estimating equations (GEE) for repeated measure data collected during exercise and rest periods.Results: During stage 1, the total cost of energy was derived from VO2 during each

exercise. Our results presented that the METs of a single training workout were 3.3 kcal for the untrained and 3.4 kcal for the trained groups, whereas the total EE was 683~688 kcal and 779~840 kcal, respectively. The respiratory exchange ratio (p = 0.010*) for the three exercises differed considera

bly, while the heart rate, systolic and diastolic blood pressure, and Borg rate of perceived exertion did not reach significant levels. During the stage 2 exercise period, RER, HR, SBP, and BL for the training group [quasi-likelihood under an independence model criterion] (QIC = 187, p = 0.0001***~0

.033*) while RER, HR, SBP, DBP, and RPE (QIC = 48, p = 0.0001***~0.002*) during the resting period for untrained group significantly estimated MET for moderate-intensity resistance training exercises. The sEMG of untrained vs. trained groups significantly computed GEE (QIC = 344, p = 0.020* vs. QIC

= 867, p = 0.018*), respectively. The predicted models for the three types of exercises for the untrained vs. trained groups were shoulder press (QIC = 129, p = 0.009* vs. QIC = 116, p = 0.001**), deadlift (QIC = 164, p = 0.003* vs. QIC = 309, p = 0.016*), and squat (QIC = 67, p = 0.009* vs. QIC = 3

65, p = 0.031*),respectively.Conclusion: The stage 1 exercise protocol of this study involved a moderate-intensity exercise of 2.4~3.9 METs. The energy cost of each training exercise was between 179~291 kcal. It is also inferred that the cardiorespiratory variables are significantly related to MET.

During stage 2, RER and HR significantly estimated MET for two groups along with SBP and BL for the training group. While during the resting period, RER, HR, SBP, DBP, and RPE related significantly for untrained and BL for training groups respectively. The models significantly predicted for the thre

e types of exercises using the right and left middle deltoid, right and left lumbar erector spinae, left rectus femoris, and right and left biceps femoris sEMG RMS for the untrained and trained groups during moderate-intensity strength training exercises.